cytotoxic activity of bioactive compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester extracted from a marine derived streptomyces sp. vitsjk8
نویسندگان
چکیده
marine streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. the cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (dmehe) from marine derived actinomycete streptomyces sp. vitsjk8 was investigated against mouse embryonic fibroblast (nih 3t3) and human keratinocyte (hacat) normal cell lines, human hepatocellular liver carcinoma (hepg 2) and human breast adenocarcinoma (mcf-7) cell lines by using mtt assay. the compound dmehe exhibited ic 50 values of 42, 100, 250 and 500 µg/ ml against hepg2, mcf-7, hacat and nih 3t3 cell lines, respectively. the effect of dmehe on the growth of cancer cell lines was expressed as the % of viability. cell viability was recorded as 67.7%, 78.14%, 82.23% and 96. 11% in hepg2, mcf-7, hacat and nih 3t3 cells, respectively. the results of the study conclude that the bioactive compound isolated from the potential isolate streptomyces sp. vitsjk8 exhibited cytotoxic activity against hepg2 and mcf- 7 cancer cell lines and low toxicity against normal hacat and nih 3t3 cell lines.
منابع مشابه
Cytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8
Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...
متن کاملCytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8
Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...
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The anti-ESBL activity of 1, 2-benzenedicarboxylic acid, mono (2-ethylhexyl) ester (DMEHE) extracted from marine Streptomyces sp strain VITSJK8 was further confirmed by in silico analysis. A total of 10 ESBL proteins was chosen for this study from the protein data bank (PDB) and were docked with the DMEHE. The resultant atomic contact energy (ACE) was compared with dockings of known antibiotic ...
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عنوان ژورنال:
international journal of molecular and cellular medicineجلد ۳، شماره ۴، صفحات ۲۴۶-۲۵۴
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